Kabachnik-Fields reactions of 2,3-Trimethylene-1,2,3,4-dihydrobenzo[2,3-d]pyrimidin-4-on

In this research article, 2,3-trimethylene-3,4-dihydrobenzo[2,3-d]pyrimidin-4-one was synthesized from 2-aminobenzoic acid and pyrrolidone-2 in the presence of various substances, such as PCl5, POCl3. Its reduction reaction with NaBH4 carried out. The resulting three-component coupling 2,3-trimethylene-1,2,3,4-tetrahydrobenzo[2,3-d]pyrimidin-4-one-carbonyl, amine, hydrophosphoryl leads to αaminophosphonates. Phosphate – formaldehyde; aldehydes system; synthesis aminomethylphosphonic is based on condensation reaction. During experiment, obtained amount 74%. yield product increased resyntheses. structures were confirmed by IR 1H NMR spectroscopies. Using NaBH4, experiment repeated 2,3-trimethylene-1,2,3,4-tetrahydrobenzo[2,3d]pyrimidin-4-one high yield. Additionally, 2,3-trimethylene-1,2,3,4-tetrahydrobenzo[2,3-d]pyrimidin-4-one related aminophosphonic acids three ring molecules